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Medication that inhibit CYP2D6 activity, such as paroxetine and quinidine, might induce diminished clearance of oxycodone which may lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.Likewise to most other opioids, oxycodone boosts prol